000			04208namaa2200481uu 4500
001			doab100138
003			oapen
005			20260305123951.0
006			m o d
007			cr|mn|---annan
008			230512s2022 xx |||||o ||| 0|eng d
020			_a9780367499327
020			_a9780367499334
020			_a9781003048138
020			_a9781003048138
024	7		_a10.1201/9781003048138 _2doi
040			_aoapen _coapen
041	0		_aeng
042			_adc
720	1		_aChondrogianni, Niki _4edt
245	0	0	_aProteostasis and Proteolysis
260			_bTaylor & Francis _c2022
300			_a1 online resource
336			_atext _btxt _2rdacontent
337			_acomputer _bc _2rdamedia
338			_aonline resource _bcr _2rdacarrier
506	0		_aFree-to-read _fUnrestricted online access _2star
520			_aProteins are the key decision-making workforce for practically all cellular signals. The precise equilibrium between protein translation, folding, function and timely degradation, also known as "proteostasis", determine cellular health as well as organismal maintenance and survival. Loss of cellular proteostasis is linked with physiological processes of deterioration such as aging, with conditions characterized by supraphysiological oxidative stress as well as with illness, including age-related diseases, neurodegeneration, inflammation, dystrophies and cancer. This book includes 18 chapters logically organized to allow comprehensive understanding of how maintenance of proteostasis protects cellular and organismal health, and how environmental and metabolic pressure can impair proteostasis and lead to disequilibrium and disease. Each chapter contains up-to-date information on its respective topic while some of them review the interplay of certain proteostatic mechanisms, a newly arising topic. Importantly, most chapters include tangible examples of how failure of proteostasis can underlie aging and disease. We hope that the compilation of the above topics will assist both novice and experienced researchers and students to become more familiar with the subject of proteostasis. In the long run, we hope that this book will inspire its readers and eventually promote new ideas and new research studies.
540			_aAll rights reserved _uhttp://oapen.org/content/about-rights
546			_aEnglish
653			_aad, age, alejandro, alihamze, anna, arantxa, aspects, assembly, Athanasopouloi, autophagy, between, cell, central, chaerone, chapter, Chondrogianni, complex, concluding, conculsions, contents, control, crosstalk, current, deciphering, definition, degradation, Diana, diseases, during, Efstathios, elF5A, Elah, Elisabeth, Factors, Farras, fathinajafabadi, Ferrando, Ferriz, folding, functions, future, gioran, gonos, heat, heidi, integrity, interplay, introsuction, irreversible, judith, kapetanou, kinetic, leading, localized, Marianna, Martinez, mechanisms, MicroRNAs, misfolding, molecular, motifs, network, Kiki, Olzscha, organellar, other, oxidative, panfilova,pathway, pauses, perspectives, pick, polu, pro, process, Proteasome, protein, proteinopathies, proteolysis, proteome, proteostasis, proteostatic, quality, references, regulation, regulators, related, remarks, rescues, response, reversible, ribosomal, riemer, rosa, RQC, S, shock,significance, sophia, stalling, stress, system, systemic, systems, table, targeting, term, thermodynamic, transcriptional , translation, translational, treatments, ubiquitin, unfolded
653			_athema EDItEUR::M Medicine and Nursing::MF Pre-clinical medicine: basic sciences
653			_athema EDItEUR::P Mathematics and Science::PN Chemistry::PNN Organic chemistry
653			_athema EDItEUR::P Mathematics and Science::PS Biology, life sciences
653			_athema EDItEUR::P Mathematics and Science::PS Biology, life sciences::PSD Molecular biology
720	1		_aChondrogianni, Niki _4oth
720	1		_aGioran, Anna _4edt
720	1		_aGioran, Anna _4oth
720	1		_aPICK, ELAH _4edt
720	1		_aPICK, ELAH _4oth
793	0		_aDOAB Library.
856	4	0	_uhttps://directory.doabooks.org/handle/20.500.12854/100138 _70 _zFree-to-read: DOAB: description of the publication
999			_c93082 _d93082