04208namaa2200481uu 4500001001100000003000600011005001700017006001900034007001500053008004100068020001800109020001800127020001800145020001800163024003100181040001700212041000800229042000700237720002900244245003300273260002700306300002200333336002600355337002600381338003600407506005100443520142500494540006301919546001201982653113401994653008403128653008203212653007203294653009503366720002903461720002203490720002203512720002003534720002003554793001803574856011703592999001703709doab100138oapen20260305123951.0m     o  d        cr|mn|---annan230512s2022    xx |||||o     ||| 0|eng d  a9780367499327  a9780367499334  a9781003048138  a97810030481387 a10.1201/97810030481382doi  aoapencoapen0 aeng  adc1 aChondrogianni, Niki4edt00aProteostasis and Proteolysis  bTaylor & Francisc2022  a1 online resource  atextbtxt2rdacontent  acomputerbc2rdamedia  aonline resourcebcr2rdacarrier0 aFree-to-readfUnrestricted online access2star  aProteins are the key decision-making workforce for practically all cellular signals. The precise equilibrium between protein translation, folding, function and timely degradation, also known as "proteostasis", determine cellular health as well as organismal maintenance and survival. Loss of cellular proteostasis is linked with physiological processes of deterioration such as aging, with conditions characterized by supraphysiological oxidative stress as well as with illness, including age-related diseases, neurodegeneration, inflammation, dystrophies and cancer. This book includes 18 chapters logically organized to allow comprehensive understanding of how maintenance of proteostasis protects cellular and organismal health, and how environmental and metabolic pressure can impair proteostasis and lead to disequilibrium and disease. Each chapter contains up-to-date information on its respective topic while some of them review the interplay of certain proteostatic mechanisms, a newly arising topic. Importantly, most chapters include tangible examples of how failure of proteostasis can underlie aging and disease. We hope that the compilation of the above topics will assist both novice and experienced researchers and students to become more familiar with the subject of proteostasis. In the long run, we hope that this book will inspire its readers and eventually promote new ideas and new research studies.  aAll rights reserveduhttp://oapen.org/content/about-rights  aEnglish  aad, age, alejandro, alihamze, anna, arantxa, aspects, assembly, Athanasopouloi, autophagy, between, cell, central, chaerone, chapter, Chondrogianni, complex, concluding, conculsions, contents, control, crosstalk, current, deciphering, definition, degradation, Diana, diseases, during, Efstathios, elF5A, Elah, Elisabeth, Factors, Farras, fathinajafabadi, Ferrando, Ferriz, folding, functions, future, gioran, gonos, heat, heidi, integrity, interplay, introsuction, irreversible, judith, kapetanou, kinetic, leading, localized, Marianna, Martinez, mechanisms, MicroRNAs, misfolding, molecular, motifs, network, Kiki, Olzscha, organellar, other, oxidative, panfilova,pathway, pauses, perspectives, pick, polu, pro, process,  Proteasome, protein, proteinopathies, proteolysis, proteome, proteostasis, proteostatic, quality, references, regulation, regulators, related, remarks, rescues,  response, reversible, ribosomal, riemer, rosa, RQC, S, shock,significance, sophia, stalling, stress, system, systemic, systems, table, targeting, term, thermodynamic, transcriptional , translation, translational, treatments, ubiquitin, unfolded  athema EDItEUR::M Medicine and Nursing::MF Pre-clinical medicine: basic sciences  athema EDItEUR::P Mathematics and Science::PN Chemistry::PNN Organic chemistry  athema EDItEUR::P Mathematics and Science::PS Biology, life sciences  athema EDItEUR::P Mathematics and Science::PS Biology, life sciences::PSD Molecular biology1 aChondrogianni, Niki4oth1 aGioran, Anna4edt1 aGioran, Anna4oth1 aPICK, ELAH4edt1 aPICK, ELAH4oth0 aDOAB Library.40uhttps://directory.doabooks.org/handle/20.500.12854/10013870zFree-to-read: DOAB: description of the publication  c93082d93082