04208namaa2200481uu 4500 doab100138 oapen 20260305123951.0 m o d cr|mn|---annan 230512s2022 xx |||||o ||| 0|eng d 9780367499327 9780367499334 9781003048138 9781003048138 10.1201/9781003048138 doi oapen oapen eng dc Chondrogianni, Niki edt Proteostasis and Proteolysis Taylor & Francis 2022 1 online resource text txt rdacontent computer c rdamedia online resource cr rdacarrier Free-to-read Unrestricted online access star Proteins are the key decision-making workforce for practically all cellular signals. The precise equilibrium between protein translation, folding, function and timely degradation, also known as "proteostasis", determine cellular health as well as organismal maintenance and survival. Loss of cellular proteostasis is linked with physiological processes of deterioration such as aging, with conditions characterized by supraphysiological oxidative stress as well as with illness, including age-related diseases, neurodegeneration, inflammation, dystrophies and cancer. This book includes 18 chapters logically organized to allow comprehensive understanding of how maintenance of proteostasis protects cellular and organismal health, and how environmental and metabolic pressure can impair proteostasis and lead to disequilibrium and disease. Each chapter contains up-to-date information on its respective topic while some of them review the interplay of certain proteostatic mechanisms, a newly arising topic. Importantly, most chapters include tangible examples of how failure of proteostasis can underlie aging and disease. We hope that the compilation of the above topics will assist both novice and experienced researchers and students to become more familiar with the subject of proteostasis. In the long run, we hope that this book will inspire its readers and eventually promote new ideas and new research studies. All rights reserved http://oapen.org/content/about-rights English ad, age, alejandro, alihamze, anna, arantxa, aspects, assembly, Athanasopouloi, autophagy, between, cell, central, chaerone, chapter, Chondrogianni, complex, concluding, conculsions, contents, control, crosstalk, current, deciphering, definition, degradation, Diana, diseases, during, Efstathios, elF5A, Elah, Elisabeth, Factors, Farras, fathinajafabadi, Ferrando, Ferriz, folding, functions, future, gioran, gonos, heat, heidi, integrity, interplay, introsuction, irreversible, judith, kapetanou, kinetic, leading, localized, Marianna, Martinez, mechanisms, MicroRNAs, misfolding, molecular, motifs, network, Kiki, Olzscha, organellar, other, oxidative, panfilova,pathway, pauses, perspectives, pick, polu, pro, process, Proteasome, protein, proteinopathies, proteolysis, proteome, proteostasis, proteostatic, quality, references, regulation, regulators, related, remarks, rescues, response, reversible, ribosomal, riemer, rosa, RQC, S, shock,significance, sophia, stalling, stress, system, systemic, systems, table, targeting, term, thermodynamic, transcriptional , translation, translational, treatments, ubiquitin, unfolded thema EDItEUR::M Medicine and Nursing::MF Pre-clinical medicine: basic sciences thema EDItEUR::P Mathematics and Science::PN Chemistry::PNN Organic chemistry thema EDItEUR::P Mathematics and Science::PS Biology, life sciences thema EDItEUR::P Mathematics and Science::PS Biology, life sciences::PSD Molecular biology Chondrogianni, Niki oth Gioran, Anna edt Gioran, Anna oth PICK, ELAH edt PICK, ELAH oth DOAB Library. https://directory.doabooks.org/handle/20.500.12854/100138 0 Free-to-read: DOAB: description of the publication 93082 93082